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sparsentan will lessen the extent or impact of modafinil by affecting hepatic enzyme CYP2C19 metabolism. Use Caution/Watch. Sparsentan (a CYP2C19 inducer) decreases exposure of CYP2C19 substrates and lessens efficacy connected with these substrates.Modafinil may perhaps minimize serum concentrations of other medicine to the clinically major extent,